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Migraine Headaches

by Charles C. Wang, M.D., Neurologist

Migraine is a type of headache. It affects about 6 out of 100 people. The World Health Organization ranks in the top 20 most disabling disorders in the world. Migraines most commonly occur in women and usually begin between the ages of 10 and 46. They appear to run in families in some cases.

Migraines are traditionally classified as classic migraine (migraine with an aura), common migraine (migraine without an aura) or mixed migraine (has features of both migraines). Classic migraine is preceded by an aura, a group of symptoms that indicates a pending migraine headache. The most common aura is the visual symptoms such as flashing light, zigzag lines, blind spots, and moving spots. There may also be numbness or weakness on one side of the body that marches up the arm, leg or face over the course of minutes. Common migraine does not have such aura. They are a common type of chronic headache. They are more common than classic migraine. Classic migraine accounts for only about one-sixth of all migraines. Common migraine and other (rare) forms account for the rest.

Migraines are sometimes triggered by lack of sleep, MSG (monosodium glutamate), alcohol, stress, certain food (chocolate), etc. Others may occur when blood vessels of the head and neck spasm or constrict, which decreases blood flow. In people who tend to have migraines, preventive medications may reduce the number of incidences of headache. In addition, it is usually recommended to avoid factors that have triggered a migraine in the past.

The symptoms of migraine include headache, which has the following characteristics: 1) throbbing, pulsating; 2) usually worst on the sides of the head; 3) may be on only one side of the head; 4) may be severe or dull; 5) commonly lasts 4 to 36 hours; 6) may be associated with nausea, vomiting, sensitivity to light and sound. An aura may precede the headache (any of various symptoms that indicate an impending migraine). Symptoms may be present during the headache and disappear after the headache is relieved (dizziness, tingling, or other symptoms).

Migraine headache may be diagnosed by the health care provider based on the pattern of symptoms, history of migraines in the family, and the response to treatment. In addition, a physical examination must show no detectable abnormalities. Sometimes an MRI is obtained to rule out other causes of headache, such as tumor, vascular malformation or aneurysm, upon initial investigation. Treatment of migraine includes multiple approaches. Resting in a quiet, darkened room often reduces the severity of symptoms. Drinking a lot of fluids is important to maintain hydration especially if there is vomiting.

Several medications may be advised to relieve symptoms. The response of migraine to medications is highly variable. If a medication has been effective in relieving a previous migraine, it may be tried before others. Over-the-counter analgesics may reduce pain if they are taken early in the development of the headache. If over-the-counter analgesics are ineffective, vasoconstricting or other medications may be helpful. Triptans (Imitrex, Zomig, Amerge, Maxalt, Frova, etc) are very effective and relatively safe medications. Ergotamine tartrate preparations constrict the arteries of the head and may be used alone or in combination with other drugs such as caffeine (Cafergot) or fioricet. Ergonovine maleate may relieve symptoms. Propoxyphene or other medications that relieve pain and/or inflammation may provide relief for some people. Nausea should be treated early with Reglan, Compazine, or other antiemetics. Severe cases may need hospitalization and steroids.

Preventive medications include propranolol, amitriptyline, ergonovine, cyproheptadine, clonidine, methysergide, calcium channel antagonists, valproic acid, and carbamazepine, or other antidepressants. New anticonvulsant, Topamax, has shown to be an effective prophylactic medication. Others include new anticonvulsants such as trileptal, lamictal, etc. Typically, several medications are tried before an effective preventative medication is found. Botox injection may also be effective.

The migraine will relieve with time. Treatment may reduce discomfort and time away from work, improve quality of life and may prevent future migraines. Rarely, people with severe migraines may have a stroke.

A consultation with your health care provider is recommended if this is the first time that you have had symptoms of migraine; migraine symptoms are severe, persistent, recurrent, or accompanied by other symptoms; if previously effective treatments are no longer helpful, or if symptoms indicating side effects of medications occur; or if you are likely to become pregnant (many medications should not be taken when pregnant).

If you are interested in scheduling an appointment with one of CINN’s headache specialists, please call 1-800-411-CINN.

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